POS0646 EFFECT OF OLOKIZUMAB ON THE NEUTROPHIL-LYMPOCYTE RATIO IN PATIENTS WITH RHEUMATOID ARTHRITIS (2024)

Methods: Post hoc analysis phase 3 studies (NCT02760368, NCT02760407, NCT02760433).

Neutrophil-lymphocyte ratio was calculated by dividing the absolute number of neutrophils (ANC) by absolute number of lymphocytes (ALC) in the venous blood (NLR=ANC/ALC). Baseline parameters and their changes were analyzed in four groups: OKZ q2w, OKZ q4w, adalimumab group (ADA) and placebo group (PBO) all at background of MTX. A Wilcoxon signed-rank test was used to evaluate the statistical significance between baseline parameters and after 12 and 24 weeks of therapy. Pearson correlation analysis was used to determine the relationship between NLR, ANC, ALC changes and the main indices of RA activity. A p-value <0.050 was considered statistically significant.

Results: NLR, ANK, ALC were studied in 4 groups of patients: OKZ q2w (n=745), OKZ q4w (n=777), ADA (n=462), PBO (n=454). The baseline levels of ANC and ALC were comparable in all four groups. NLR baseline level in the appropriate groups Me[Q1,Q3]: 3.12[2.24; 4.44], 3.21[2.33; 4.37], 3.21[2.35; 4.48], 3.21[2.44; 4.77]. NLR decrease had been recorded in all active therapy groups, respectively 34.3%, 33.0%, 32.0% (vs BL p < 0.001) after 12 weeks of therapy. NLR decrease was minimal in the placebo group (2.8%, vs BL p>0.05). After 24 weeks of therapy, the NLR decrease had been 33.0%, 29.6%, 31.8% in the active therapy groups (vs BL p<0.001), 6.5% in the placebo group (p<0.001). The NLR reduction occurred due to ANC decrease, with unchanged ALC in the OKZ groups. In ADA group ANC decreased less, but ALC increased (Figure 1). Correlation analysis revealed a positive weak relationship between changes in DAS28, CRP, ESR and ΔANC, ΔNLR, and a negative correlation with ΔALC. CDAI changes were not associated with changes of hematological parameters (Table 1).

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